Spoed!
Menu

PubMed publicaties

Sinds begin jaren 60 zijn er veel wetenschappelijke artikelen gepubliceerd over de schadelijke effecten van Softenon op de ongeboren vrucht en op de ouder wordende Softenon slachtoffers. Een verzameling van de meest recent gepubliceerde artikelen vindt u hieronder. De volledige lijst met titels en abstracts kunt u vinden, door hier te klikken.

4.7 Medische informatie_Pubmed publicaties.jpg

2017 Impact Thalidomide use Brazil. Er wordt met een kritische blik gekeken naar de geschiedenis van Thalidomide in Brazilie en naar het voorkomen van Thalidomide Embryopathie in de afgelopen decennia.

2015 Blood pressure in thalidomide-impaired patient. Een publicatie van anesthesie bij een Softenon slachtoffer zonder armen en met benen waarbij ovariumcystectomie wordt uitgevoerd.

Apr 2021 A drug repositioning success: The repositioned therapeutic applications and mechanisms of action of thalidomide.
Thalidomide is the most teratogenic human medicine ever marketed and was associated with birth defects in approximately 10,000 children in the 1960s. The pharmacological effects of thalidomide are attributed to its an...

10 2020 Thalidomide in the treatment of erythema nodosum leprosum (ENL) in an outpatient setting: A five-year retrospective analysis from a leprosy referral centre in India.
Erythema nodosum leprosum (ENL), or type 2 lepra reaction, is a multi-system immune-mediated complication in patients with multibacillary leprosy, frequently associated with chronicity and recurrences. Management of E...

09 2020 Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide.
Thalidomide and its derivatives exert not only therapeutic effects as immunomodulatory drugs (IMiDs) but also adverse effects such as teratogenicity, which are due in part to different C2H2 zinc-finger (ZF) transcript...

08 2020 Placental transfer and safety in pregnancy of medications under investigation to treat coronavirus disease 2019.
Treatment of coronavirus disease 2019 is mostly symptomatic, but a wide range of medications are under investigation against severe acute respiratory syndrome coronavirus 2. Although pregnant women are excluded from c...

08 2020 The organization, weaknesses, and challenges of the control of thalidomide in Brazil: A review.
The drug thalidomide has resurged in the world market under restrictive conditions for marketing and use. In Brazil, there are still cases of pregnant women using thalidomide even after the implementation of laws that...

Oct 2020 Thalidomide use in the management of oromucosal disease: A 10-year review of safety and efficacy in 12 patients.
Thalidomide is an effective systemic agent in the management of ulcerative oromucosal conditions. However, its clinical use is limited because of its known adverse effect profile, including teratogenicity, peripheral ...

2020 Molecular mechanisms of thalidomide and its derivatives.
Thalidomide, originally developed as a sedative drug, causes multiple defects due to severe teratogenicity, but it has been re-purposed for treating multiple myeloma, and derivatives such as lenalidomide and pomalidom...

Jul 2020 Recent advances in the molecular mechanism of thalidomide teratogenicity.
Thalidomide was first marketed in 1957 but soon withdrawn because of its notorious teratogenicity. Studies on the mechanism of action of thalidomide revealed the pleiotropic properties of this class of drugs, includin...

04 2020 Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex.
Thalidomide-dependent degradation of the embryonic transcription factor SALL4 by the CRL4 E3 ubiquitin ligase is a plausible major driver of thalidomide teratogenicity. The structure of the second zinc finger of SALL4...

2020 A novel screening test to predict the developmental toxicity of drugs using human induced pluripotent stem cells.
In vitro human induced pluripotent stem (iPS) cells testing (iPST) to assess developmental toxicity, e.g., the induction of malformation or dysfunction, was developed by modifying a mouse embryonic stem cell test (EST...

A A Vergroot
Print
Nesos ZonMw Ministerie van volksgezondheid, welzijn en sport ZonMw
Ministerie van volksgezondheid, welzijn en sport
ZonMw
ZonMw