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PubMed publicaties

Sinds begin jaren 60 zijn er veel wetenschappelijke artikelen gepubliceerd over de schadelijke effecten van Softenon op de ongeboren vrucht en op de ouder wordende Softenon slachtoffers. Een verzameling van de meest recent gepubliceerde artikelen vindt u hieronder. De volledige lijst met titels en abstracts kunt u vinden, door hier te klikken.

4.7 Medische informatie_Pubmed publicaties.jpg

2017 Impact Thalidomide use Brazil. Er wordt met een kritische blik gekeken naar de geschiedenis van Thalidomide in Brazilie en naar het voorkomen van Thalidomide Embryopathie in de afgelopen decennia.

2015 Blood pressure in thalidomide-impaired patient. Een publicatie van anesthesie bij een Softenon slachtoffer zonder armen en met benen waarbij ovariumcystectomie wordt uitgevoerd.

Mar 2022 [Otorhinolaryngological diseases in pregnancy-which drugs are approved?]
Between 1958 and 1961 approximately 10,000 children with severe deformities of extremities were born, whose mothers had taken the sedative thalidomide. Since then, drugs in pregnancy are applied with legitimate cautio...

03 2022 The Ubiquitination-Dependent and -Independent Functions of Cereblon in Cancer and Neurological Diseases.
Cereblon (CRBN) mediates the teratogenic effect of thalidomide in zebrafish, chickens, and humans. It additionally modulates the anti-myeloma effect of the immunomodulatory drugs (IMiDs) thalidomide, lenalidomide, and...

Mar 2022 Integrated fibroblast growth factor signal disruptions in human iPS cells for prediction of teratogenic toxicity of chemicals.
The number of man-made chemicals has increased rapidly in recent decades, with certain chemicals potentially causing malformations in fetuses. Although the toxicities of chemicals have been tested in animals, chemical...

03 2022 Esco2 and cohesin regulate CRL4 ubiquitin ligase expression and thalidomide teratogenicity.
Cornelia de Lange syndrome (CdLS) and Roberts syndrome (RBS) are severe developmental maladies that arise from mutation of cohesin (including , CdLS) and (RBS). Though ESCO2 activates cohesin, CdLS and RBS etiologies...

Apr 2022 The role of thalidomide in dermatology.
Thalidomide is a medication that has been in existence for over half a century, and has proven to be useful and effective in severe dermatological conditions. For dermatologists, the ability of thalidomide to reduce t...

Sep 2021 Thalidomide control and use: are these appropriate to extend the use and mitigate the risk of teratogenicity in Brazil?
Drug utilization research to describe the control of thalidomide in Brazil and its use in Minas Gerais state. An online questionnaire was sent to the Brazilian federative units to collect data concerning distribution,...

10 2021 USP15 antagonizes CRL4-mediated ubiquitylation of glutamine synthetase and neosubstrates.
Targeted protein degradation by the ubiquitin-proteasome system represents a new strategy to destroy pathogenic proteins in human diseases, including cancer and neurodegenerative diseases. The immunomodulatory drugs (...

[Thalidomide and unilateral limb defects: the Italian chapter of a neverending story].
Fifty years after the event, Italy introduced legislation to compensate malformations in children - now in their sixties - born to mothers who had been prescribed the antiemetic drug thalidomide for morning sickness. ...

11 2021 Systematising Pharmacovigilance Engagement of Patients, Healthcare Professionals and Regulators: A Practical Decision Guide Derived from the International Risk Governance Framework for Engagement Events and Discourse.
Input from patients and healthcare professionals to regulatory assessments is essential for benefit-risk management of medicines. How to best obtain input in different risk scenarios is uncertain.

11 2021 Implementation of a Pregnancy Prevention Programme (PPP) with a Controlled Distribution System (CDS) for the Generic Teratogenic Phthalimides Thalidomide, Lenalidomide and Pomalidomide.
Thalidomide (α-phthalimidoglutaride) was marketed in the 1950s and early 1960s; it was promoted as a sedative-hypnotic agent with minimal hangover. It was available in some countries as an over-the-counter medicine. ...

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